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Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus

✍ Scribed by Kim, Eung-Soo; Bibb, Maureen J.; Butler, Michael J.; Hopwood, David A.; Sherman, David H.

Book ID
123347511
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
244 KB
Volume
141
Category
Article
ISSN
0378-1119

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✍ Swan, David G. ;RodrΓ­guez, Ana M. ;Vilches, Carmen ;MΓ©ndez, Carmen ;Salas, JosΓ© πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 779 KB

A gene (ORFB) from Streptomyces antibioticus (an oleandomycin producer) encoding a large, multifunctional polyketide synthase (PKS) was cloned and sequenced. Its product shows an internal duplication and a close similarity to the third subunit of the PKS involved in erythromycin biosynthesis by Sacc