Sequence variation in the SRC gene product affects metastasis formation: The central, but not exclusive, role of the tumor immune response
✍ Scribed by Robert L. Taylor Jr.; James M. England; Gene C. Kopen; Alexander A. Christou; Michael S. Halpern
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 390 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Sequence variation in the src gene product could, in principle, influence metastasis formation through either of 2 effects: an alteration in tumor antigenicity or a non-immune-mediated change in one or more src-associated functions. Our present results establish that both mechanisms underlie the difference in relative levels of metastasis formation induced by the v-src vs. the c-src(527) oncogene. A point that emerges from this analysis is the segregation, within a chicken line genotypically uniform at the major histocompatibility (6) complex (MHC), of a phenotype defined by strong resistance to secondary v-src- induced tumor challenge. The pattern of segregation is consonant with the possibility that a gene unlinked to the MHC governs immune response levels to v-src-encoded tumor antigen.