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Sequence Variation in the Gene Encoding the Nonstructural 3 Protein of Hepatitis C Virus: Evidence for Immune Selection

✍ Scribed by Huiru Wang; Tonghua Bian; Stephen J. Merrill; David D. Eckels


Publisher
Springer
Year
2002
Tongue
English
Weight
378 KB
Volume
54
Category
Article
ISSN
0022-2844

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Hypervariable region I (HVRI) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) undergoes sequential alterations at intervals of several months during the chronic phase of hepatitis. To evaluate the implications of sequence variability in HVRl of HCV, we investigated the