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Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprtgene in CHO cells

✍ Scribed by M. Mazur; B. W. Glickman


Book ID
112557701
Publisher
Springer
Year
1988
Tongue
English
Weight
556 KB
Volume
14
Category
Article
ISSN
1572-9931

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## Abstract Glutathione (GSH) conjugation of (+)‐anti‐benzo[__a__]pyrene‐7,8‐diol‐9,10‐epoxide [(+)‐anti‐BPDE], the activated metabolite of benzo[__a__]pyrene, is believed to be an important mechanism in detoxification of this environmental and dietary carcinogen. Here, we demonstrate that the intr