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Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole−Imidazole Polyamides

✍ Scribed by Shinohara, Ken-ichi; Narita, Akihiko; Oyoshi, Takanori; Bando, Toshikazu; Teraoka, Hirobumi; Sugiyama, Hiroshi

Book ID
126236080
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
339 KB
Volume
126
Category
Article
ISSN
0002-7863

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## Abstract To extend the target DNA sequence length of the hairpin pyrrole–imidazole (Py–Im) polyamide **1**, we designed and synthesized Y‐shaped and tandem hairpin Py–Im polyamides **2** and **3**, which possess 1‐(chloromethyl)‐5‐hydroxy‐1,2‐dihydro‐3__H__‐benz[__e__]indole (__seco__‐CBI) as DN