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Sequence-specific alkylation of double-helical DNA by oligonucleotide-directed triple-helix formation

✍ Scribed by Povsic, Thomas J.; Dervan, Peter B.


Book ID
126154874
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
918 KB
Volume
112
Category
Article
ISSN
0002-7863

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## Abstract __Oligonucleotide‐directed triple‐helix formation provides a rational means to interfere with genomic DNA targets and to direct modifications at specific sites. We have developed a new class of compounds that, at low concentrations, efficiently targets and damages double‐stranded DNA sp