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Sequence of the rabbit neurofilament protein L

โœ Scribed by D. R. Soppet; L. L. Beasley; M. B. Willard

Book ID
102912025
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
579 KB
Volume
30
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

In the course of screening a rabbit brain cDNA library with a probe for the H neurofilament protein, we identified a neurofilament L-cDNA. Its nucleotide sequence is 88% identical to that of human, indicating that L is highly conserved among species. The similarities between the sequences of L from rabbit and mouse suggest that the species-specific accumulation of neurofilaments that occurs in rabbit during aluminum intoxication is not a consequence of the primary structure of L.

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cDNA coding for the tail region of the high molecular weight rabbit neurofilament protein NF-H
โœ K. Mack; J. R. Currie; Dr. David Soifer ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 744 KB

A cDNA library was prepared from rabbit brain mRNA, in the expression vector, lambda gt11. The library was screened with polyclonal antibodies raised against the neurofilament protein NF-H, and a cloned cDNA (KMRH-1) was selected and characterized. The fusion protein coded for by KMRH-1 includes epi