Sequence heterogeneity of the hepatitis C virus envelope region
โ Scribed by Cariani, Elisabetta; Zonaro, Antonella; Puoti, Massimo; Primi, Daniele
- Book ID
- 122103228
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 138 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0168-8278
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GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of het
How Hepatitis C Virus (HCV) causes persistent infection is unknown. One hypothesis is that HCV evades the host immune response through mutation in immune epitopes. We have investigated mutations in the HCV genome to see if they cluster within immune epitopes; and we have studied the effect of antibo