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Sequence and Evolution of HLA-DR7- and -DRw53-Associated β -Chain Genes

✍ Scribed by John A. T. Young, David Wilkinson, Walter F. Bodmer and John Trowsdale

Book ID
123634740
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
759 KB
Volume
84
Category
Article
ISSN
0027-8424

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✍ Jack Gorski; Pierre Rollini; Bernard Mach 📂 Article 📅 1987 🏛 Springer-Verlag 🌐 English ⚖ 651 KB

The organization and sequence of the HLA-DR beta chain genes are compared in the two supertypic groups, DRw52 and DRw53, which together account for more than 80% of HLA-DR alleles. From the structural data, we conclude that these two groups represent distinct lineages which have followed different p