Sequence and crystal structure determination of a basic phospholipase A2 from common krait (Bungarus caeruleus) at 2.4 Å resolution: identification and characterization of its pharmacological sites

Simultaneous inhibition of anti-coagulat

Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 Å resolution reveals the presence of the new common ligand-binding site

✍ Nagendra Singh; Ramasamy Prem Kumar; Sanjit Kumar; Sujata Sharma; Rafia Mir; Pun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract A novel ligand‐binding site with functional implications has been identified in phospholipase A~2~ (PLA~2~). The binding of non‐steroidal anti‐inflammatory agent indomethacin at this site blocks both catalytic and anti‐coagulant actions of PLA~2~. A group IIA PLA~2~ has been isolated fr