The X protein (HBx) of the human Hepatitis B Virus (HBV) is a regulatory protein that exercises a transcriptional activator function on a variety of regulatory elements and is therefore considered to be involved in the development of human hepatocellular carcinoma (HCC). So far, most attempts at elu
Sequence analysis of a parvovirus B19 isolate and baculovirus expression of the non-structural protein
β Scribed by K. E. Hicks; R. C. N. Cubel; B. J. Cohen; J. P. Clewley
- Publisher
- Springer Vienna
- Year
- 1996
- Tongue
- English
- Weight
- 703 KB
- Volume
- 141
- Category
- Article
- ISSN
- 1432-8798
No coin nor oath required. For personal study only.
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The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509-4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Further
To assess the prevalent genetic types of human parvovirus B19 strains derived from various sources and their relation to particular clinical symptoms, the genetic diversity in the VP1 unique region, which is important for the neutralizing response to human parvovirus B19, was examined by the mismatc