Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle
✍ Scribed by Curtis J Wray; Joshua M.V Mammen; Dan D Hershko; Per-Olof Hasselgren
- Book ID
- 117755993
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 103 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1357-2725
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## Abstract In order to gain insight into intracellular mechanisms involved in longitudinal growth of skeletal muscle, we determined gene expression of ubiquitin‐ligases (MAFbx/atrogin‐1, E3 alpha, and MuRF‐1) and deubiquitinating enzymes (UBP45, UBP69, and USP28) at different time‐points (24, 48,
## Abstract Muscle wasting is commonly seen in patients with hyperthyroidism and is mainly caused by stimulated muscle proteolysis. Loss of muscle mass in several catabolic conditions is associated with increased expression of the muscle‐specific ubiquitin ligases atrogin‐1 and MuRF1 but it is not