A high-resolution capillary isoelectric
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Jun Lin; Qingqiao Tan; Shaoxiong Wang
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Article
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2011
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John Wiley and Sons
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English
β 246 KB
## Abstract Capillary isoelectric focusing (CIEF) is a common choice for separation and analysis of the charge variants and impurities of therapeutic proteins. In this study, we developed a sensitive CIEF analysis method for determining the charge heterogeneity of therapeutic monoclonal antibody (m