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Separation of the Isoforms of a Monoclonal Antibody by Gel Isoelectric Focusing, High Performance Liquid Chromatography and Capillary Isoelectric Focusing

✍ Scribed by Silverman, C.; Komar, M.; Shields, K.; Diegnan, G.; Adamovics, J.


Book ID
111962290
Publisher
Informa UK (Taylor & Francis)
Year
1992
Tongue
English
Weight
452 KB
Volume
15
Category
Article
ISSN
0148-3919

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## Abstract Capillary isoelectric focusing (CIEF) is a common choice for separation and analysis of the charge variants and impurities of therapeutic proteins. In this study, we developed a sensitive CIEF analysis method for determining the charge heterogeneity of therapeutic monoclonal antibody (m