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Separation of the enantiomers of anticonvulsant tricyclic pyrroloimidazolones by enantioselective HPLC. A chiral recognition model and a chiroptical study

✍ Scribed by Salvatore Caccamese; Grazia Principato; Alba Chimirri; Silvana Grasso

Book ID
103977622
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
389 KB
Volume
7
Category
Article
ISSN
0957-4166

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✦ Synopsis

The enantiomers of several pyrrolobenzimidazolone and pyrroloimidazopyridine derivatives have been successfully resolved by HPLC on a Whelk-O 1 Chiral Stationary Phase superior to other CSPs. A chiral recognition model explained the substituent effects on the enantioselectivity and afforded correlation of the elution order of the enantiomers to their absolute configuration. The exciton coupling method was applied to the CD spectra of the isolated enantiomers to confirm their absolute configuration.

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Structure-enantioselectivity relationships for the study of chiral recognition in peptide enantiomer separation on cinchona alkaloid-based chiral stationary phases by HPLC: Influence of the N-terminal protecting group
✍ Christoph Czerwenka; Michael Lämmerhofer; Wolfgang Lindner 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 314 KB

## Abstract Eleven different N‐terminal protecting groups (acetyl, benzoyl, FMOC, etc.) were employed for the HPLC separation of oligoalanine peptide enantiomers containing up to six amino acids. Isocratic HPLC separations were performed using a hydro‐organic buffered mobile phase and 4 mm ID colum