Separation of Spliceosome Assembly from
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Steven G. Chaulk; Andrew M. MacMillan
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Article
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2001
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John Wiley and Sons
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English
β 112 KB
Getting spliced? Pre-mRNA splicing is catalyzed by the spliceosome, a complex assembly of proteins and RNA, which forms in an ordered fashion on the substrate. If one of the residues of the substrate is caged with a photolabile o-nitrobenzyl group, the splicing reaction can be transiently blocked, u