Separation of o-, m- and p-phthalic acids by high-field asymmetric waveform ion mobility spectrometry (FAIMS) using mixed carrier gases

✍ Scribed by David A. Barnett; Randy W. Purves; Barbara Ells; Roger Guevremont

• Book ID: 101320705
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 88 KB
• Volume: 35
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/1096-9888(200008)35:8<976::aid-jms25>3.0.co;2-q

✦ Synopsis

Baseline separation of the three isomers of phthalic acid was achieved in a mixed gas system containing a 95 : 5 mixture of N(2) and CO(2), even though the acids could not be distinguished by high-field asymmetric waveform ion mobility spectrometry (FAIMS) when either pure N(2) or pure CO(2) was used as the carrier gas. Pseudomolecular anions of o-, m- and p-phthalic acids were generated by electrospray ionization and detected, following separation by FAIMS, using a quadrupole mass spectrometer. Addition of small amounts of CO(2) to an N(2) carrier gas also caused the compensation voltages to increase by as much as 12 V, accompanied by 2-7-fold improvements in the measured ion current and dramatic reductions in both adduct ion formation and parent ion fragmentation. Copyright 2000 John Wiley & Sons, Ltd.