Separation of monoterpene hydrocarbon enantiomersvia complexation with α-cyclodextrin in RP-HPLC

✍ Scribed by Zukowski, Janusz ;Pawlowska, Maria

• Book ID: 102352603
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 304 KB
• Volume: 16
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240160814

✦ Synopsis

the hghest chral separation factor among the test compounds studied (Figure 1) As expected, due to the lack of an active hydrogen in the tnfluoroacetyl (TFA) denvative of a-(methylam-nomethy1)benzyl alcohol, the chiral selectimty is smaller (and separation can only be achieved at a lower temperature) than for the TFA denvative of 2-ammo-1 -phenylethanol Interestingly, the enantiomers of some of the smaller ahphatic amnes and armno alcohols tested so far could not be separated, indicating the importance of stenc hmdrance in the separation process ~ Acknowledgments Partial financial support for t h s prolect was provided by the National Science Foundation (CH-8919151), the Dow Chemical Company (Midland, MI), and Beckmann Instruments (Fullerton, CA) Gram Processing Corporation (Muscatine, 10) is acknowledged for promding us with the corn syrup polysacchandes samples used in this study 9400 9300 9200