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Separation of cephalosporins on thin silica gel layers impregnated with transition metal ions and by reversed-phase TLC

✍ Scribed by Ravi Bhushan; G. Thuku Thiong'o

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 99 KB
Volume: 16
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.122

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✦ Synopsis

Abstract

Cephalosporin antibiotics were separated on thin layer plates impregnated with transition metal ions, Mn^2+^, Fe^2+^, Co^2+^, Ni^2+^ and Cu^2+^, using different concentrations. Various solvent systems were developed for the study and were used for separation of these analytes. Impregnation was observed to have an effect on hR~F~ values, removed tailing of analytes and improved the resolution. The results have been discussed for each metal ion and compared, and the best conditions of separation have been identified. Activation time of thin layer plates impregnated with 0.1% FeSO~4~ was found to affect both hR~F~ values and resolution of cephalosporins. New solvent systems are reported for both normal phase and reversed‐phase TLC. Copyright © 2002 John Wiley & Sons, Ltd.

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