Separation, determination of solute-micelle association constants, and hydrophobicity quantitation for a group of dihydropyridines by micellar electrokinetic chromatography

✍ Scribed by Inés Benito; Ma Angeles García; José Carlos Díez-Masa; Ma Luisa Marina

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 186 KB
• Volume: 9
• Category: Article
• ISSN: 1040-7685
• DOI: 10.1002/(sici)1520-667x(1997)9:2<87::aid-mcs5>3.0.co;2-1

✦ Synopsis

Solute-micelle association constants for a group of 26 1,4-dihydropyridines with sodium dodecyl sulfate micelles were determined by micellar electroki-Ž . netic chromatography with 2-N-cyclohexylamino -ethanesulfonic acid as separa-Ž tion buffer in aqueous media and in the presence of alcohols n-propanol and . n-butanol . Multicomponent mixtures of solutes were separated to reduce the time in measuring association constants. Hydrophobicity quantitation of 1,4-dihydropyridines from MEKC capacity factors was performed. ᮊ John Wiley & Sons, Inc.