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Separation, Detection and Estimation of C21 17: 20-Dihydroxy-20-methyl-steroids

โœ Scribed by COX, R. I.


Book ID
109597814
Publisher
Nature Publishing Group
Year
1958
Tongue
English
Weight
211 KB
Volume
181
Category
Article
ISSN
0028-0836

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In the search for potent inhibitors of P450 17, the key enzyme of androgen biosynthesis, the 20,21-aziridinyl- and 20-aminopregnene steroids 1-11 were synthesized and tested toward rat testicular P450 17. Only the aziridinyl-substituted pregnenolones (1 and 2) and progesterones (3 and 4), respective