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Separation by high-performance liquid chromatography of α- and β-amino acids: Application to assays of lysine 2,3-aminomutase and leucine 2,3-aminomutase

✍ Scribed by D.John Aberhart

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
425 KB
Volume
169
Category
Article
ISSN
0003-2697

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✦ Synopsis

Several pairs of alpha- and beta-amino acids were well separated as the ortho-phthalaldehyde derivatives by reversed phase HPLC. These included alpha- and beta-lysine, leucine, tyrosine, serine, aminoisobutyric acid, and beta-hydroxyvaline and its positional isomer. The separation was applicable to assays of lysine 2,3-aminomutase and leucine 2,3-aminomutase. However, for unknown reasons, no leucine 2,3-aminomutase activity could be found in rat liver homogenate.

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