Separation and quantification of perfusion and BOLD effects by simultaneous acquisition of functional I0- and T-parameter maps
✍ Scribed by A.-C. Schulte; O. Speck; C. Oesterle; J. Hennig
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 243 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.1109
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✦ Synopsis
Abstract
The nature of the coupling between neuronal activity and the hemodynamic response is the subject of intensive research. As a means to simultaneously measure parametric changes of T, initial intensity (I~0~) and perfusion with high temporal resolution, a multi‐image EPI technique with slice‐selective inversion recovery (ssIR) for arterial spin labeling was developed and implemented. Comparative measurements with and without the preceding slice‐selective inversion pulse were performed. I~0~ and R changes induced by primary visual stimulation were separated. For ssIR‐multi‐image EPI the average change of I~0~ over all 12 subjects was 3.4%, corresponding to a perfusion change of 40 ml/min/100 g, whereas only minor I~0~ changes were observed without inversion. On average, the R of the activated pixels changed by –0.62 sec^−1^ without inversion, while a significantly reduced average R change of –0.46 sec^−1^ was calculated for ssIR‐multi‐image EPI due to a decreased BOLD effect contribution of the intravascular compartment. Magn Reson Med 45:811–816, 2001. © 2001 Wiley‐Liss, Inc.