𝔖 Bobbio Scriptorium
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Separation and determination of thiamine, pyrithiamine, pyridine, 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(β-hydroxyethyl)thiazole by reversed-phase high-performance liquid chromatography

✍ Scribed by Bhinyo Panijpan; Mieko Kimura; Yoshinori Itokawa


Book ID
104144895
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
177 KB
Volume
258
Category
Article
ISSN
1873-3778

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## 2-Amino -1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine found in cooked meat. It is metabolically activated by the human cytochrome P450 enzymes to form the carcinogenic metabolite N 2 -OH-PhIP. PhIP has been found to induce tumors in rats and is