✦ LIBER ✦

Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: Recurrence and survival study

✍ Scribed by Fernando Gomez-Rivera; Alfredo Santillan; Andrea Barber McMurphey; George Paraskevopoulos; Dianna B. Roberts; Victor G. Prieto; Jeffrey N. Myers

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 154 KB
Volume: 30
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20875

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN).

Methods.

We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution.

Results.

One hundred thirteen patients underwent SLN biopsy for CMHN in a 12‐year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive‐SLNs were identified in 21%. With a median follow‐up of 34 months, 28% recurred. Disease‐free survival (DFS) and overall survival (OS) rates were 66% and 78% in patients with SLN‐negative, and 39% and 62% in SLN‐positive disease. In multivariate analysis, greater Breslow‐thickness was associated with decreased DFS rate (HR 2.07, CI 1.04–4.09), and age >60 years (HR 3.53, CI 1.32–9.4) with lower 5‐year OS rate.

Conclusion.

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