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Sentinel lymph node biopsy in melanoma patients: the medical oncologist's perspective

✍ Scribed by Paola Queirolo; Paola Taveggia; Marco Gipponi; Mario Roberto Sertoli

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
59 KB
Volume
85
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

With the advent of sentinel node (sN) biopsy in melanoma patients, elective lymph node dissection (ELND) can be considered an exceeded procedure. Regardless of the possible therapeutic benefits, sN biopsy efficiently predicts prognosis avoiding the morbidity rate of ELND. The importance of the sN is underlined by multivariate analyses, which show that the sN status represents the most important prognostic factor influencing disease‐free and distant disease‐free survival in patients with stage I and II melanoma. Moreover, sN biopsy provides a minimally invasive method for identifying those patients with subclinical nodal metastasis who actually have stage III disease, with a very high risk of occult distant metastases and who may benefit by adjuvant therapy. J. Surg. Oncol. 2004;85:162–165. Β© 2004 Wiley‐Liss, Inc.

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