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Sensory alien hand syndrome in corticobasal degeneration: A cerebral blood flow study

โœ Scribed by Julien Delrieu; Pierre Payoux; Olivier Toulza; Jean-Paul Esquerre; Bruno Vellas; Thierry Voisin

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
560 KB
Volume
25
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Abstract

The presence of alien hand syndrome (AHS) is suggestive of the diagnosis of corticobasal degeneration when it develops in a progressive way. Sensory AHS (sAHS) should be distinguished from the motor form described more commonly. The physiopathology of sAHS remains unclear. The aim of this study is to determine cerebral regions involved in sAHS. We compared perfusion single photon emission computer tomography scans of patients with sAHS (n = 3) and without (n = 4). We observed significant decrease of regional cerebral blood flow over the nondominant thalamus in sAHS+ compared to sAHSโˆ’ patients. This result suggests the involvement of the nondominant thalamus in sAHS. ยฉ 2010 Movement Disorder Society

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## Abstract Corticobasal degeneration (CBD) is a rare syndrome characterised by an asymmetrical rigidity with localised cortical signs, particularly apraxia. Using positron emission tomography, abnormal patterns of cortical metabolism have recently been shown. We have studied patterns of regional c