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Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition

✍ Scribed by Venkatesha, Venkatasubbaiah A.; Parsels, Leslie A.; Parsels, Joshua D.; Zhao, Lili; Zabludoff, Sonya D.; Simeone, Diane M.; Maybaum, Jonathan; Lawrence, Theodore S.; Morgan, Meredith A.


Book ID
123448452
Publisher
Neoplasia Press
Year
2012
Tongue
English
Weight
501 KB
Volume
14
Category
Article
ISSN
1522-8002

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## Abstract Paclitaxel (Taxol) is the most‐prescribed anti‐mitotic agent for a variety of advanced metastatic cancers. It induces mitotic arrest leading to apoptosis through microtubule stabilization. Chk1 is the major cell‐cycle checkpoint kinase mediating S‐ and G2‐arrests in response to various