Sensitivity to bleomycin and hydrogen peroxide of DNA repair-defective mutants in Neurospora crassa
✍ Scribed by Käfer, Etta; Luk, Dorothy
- Book ID
- 123528252
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 562 KB
- Volume
- 217
- Category
- Article
- ISSN
- 0921-8777
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A UV-sensitive mutant has been isolated from UV-mutagenized conidia of Neurospora crassa. The mutation responsible for the lesion was mapped in linkage group VL, proximal to the nucleolus organizer region. We designated the mutant mus-18. The sensitivity of the mus-18 mutant to UV-irradiation was no
Previous work in other laboratories has shown that several mutagen sensitive mutants of Neurospora crassa are extremely sensitive to low levels of histidine in the culture medium. We have shown that wild type Neurospora accumulates nicks or breaks in the DNA in the presence of histidine. The number