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Sensitivity of the Human Cough Reflex: Effect of Inflammatory Mediators Prostaglandin E 2 , Bradykinin, and Histamine

✍ Scribed by Choudry, Nozhat B.; Fuller, Richard W.; Pride, Neil B.

Book ID
121850810
Publisher
American Thoracic Society
Year
1989
Tongue
English
Weight
471 KB
Volume
140
Category
Article
ISSN
1073-449X

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## Abstract In fura‐2‐loaded human periodontal ligament (HPDL) cells, bradykinin induced a rapidly transient increase and subsequently sustained increase in cytosolic Ca^2+^ ([Ca^2+^]~i~). When external Ca^2+^ was chelated by EGTA, the transient peak of [Ca^2+^]~i~ was reduced and the sustained lev