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Sensitivity of Syrian golden hamster fetal lung cells to benzo[a]pyrene and other polycyclic hydrocarbons in vitro

✍ Scribed by Makito Emura; Hans-Bernhard Richter-Reichhelm; Peter Schneider; Ulrich Mohr


Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
247 KB
Volume
17
Category
Article
ISSN
0300-483X

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## Abstract Standardized procedures were developed to compare quantitatively the toxic and transforming effects of ten environment‐related polycyclic aromatic hydrocarbons (PAH's) using early passage mixed cultures of fetal Syrian golden hamster lung cells. Evaluation of toxicity was attempted by a

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## BACKGROUND. Because only a fraction of smokers develop neoplastic lesions, host factors may affect their susceptibility to the carcinogenic effects of tobacco smoke. Benzo[a]pyrene diol epoxide (BPDE) is the metabolic product of benzo[a]pyrene (B[a]P), a constituent of tobacco smoke. Therefore,