Sensitivity of selected drug biotransformation enzymes to dietary protein levels in adult F344 male rats

✍ Scribed by Butler, L. E. ;Dauterman, W. C.

• Book ID: 102298661
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 188 KB
• Volume: 4
• Category: Article
• ISSN: 0887-2082
• DOI: 10.1002/jbt.2570040112

✦ Synopsis

Adult male Fischer 344 rats were fed inadequate, adequate, and excessive quantities of dietary protein (8, 12, and 22O/0, respectively) for a period of 14 days. An increase in dietary protein did not increase liver weight but resulted in an increase in cytochrome P-450 content and 7-ethoxycoumarin 0deethylase activity. No significant difference in glutathione S-transferase activity was observed at the three protein levels. The in vivo hepatotoxicity of bromobenzene increased with an elevation in dietary protein intake from 12 to 22%. These data from mature rats follow trends similar to findings we have reported previously with juvenile rats.