Sensitivity of human lymphocytes to antiproliferative action of glucocorticoids and receptor efficiency
β Scribed by E. A. Kalashinikova; A. L. Pukhal'skii; V. N. Lyashko
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 160 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0007-4888
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## Abstract We have established optimal conditions for the measurement of glucocorticoid receptors (GR) in human white cells using a wholeβcell binding assay with [^3^H]dexamethasone as the ligand, and the subsequent determination of the GR content in normal human lymphocytes and in leukemic cells
Many studies of ultrasonic hemolysis have used erythrocytes; other blood cells are less well studied. The hypothesis tested was that human lymphocytes, being large and relatively fragile, are more sensitive to sonolysis than are erythrocytes at equivalent cell concentrations. Human lymphocytes (RPMI