Sensitivity and specificity of a self-administered questionnaire for familial screening of adult-onset dystonia
✍ Scribed by Maria Stella Aniello; Davide Martino; Gianluca Masi; Paolo Livrea; Giovanni Defazio
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 63 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
We developed a self‐administered questionnaire for screening the most common adult‐onset dystonias. It was tested in 90 first‐degree relatives of 22 adult‐onset dystonia patients, yielding 79% sensitivity and 94% specificity. Simulation of a case‐finding procedure based on serial application of the questionnaire and clinical examination of both subjects screening positive and subjects screening negative who had < 8 years of schooling increased sensitivity to 95% and specificity to 100%. This questionnaire may be an important screening resource for familial aggregation studies to be used in the context of a complex case‐finding procedure. © 2005 Movement Disorder Society