โ Scribed by Srivastava, B. S.
No coin nor oath required. For personal study only.
The alga Phormidium mucicola was found quite sensitive to antibiotics. Several strains resistant to streptomycin and penicillin were isolated following single and several contacts of antibiotics respectively. The resistant character remained stable during subcultures in drug-free medium. However, to isolate a fully stable and resistant strain of a concentration of penicillin two additional exposures to the same dose were required, unless otherwise, resistance was gradually lost during subcultures in penicillin-free media. This observation has been attributed to the heterogeneous nature of the resistant clones. Neither streptomycin nor penicillin resistant strains revealed cross-resistance ~o ultraviolet (u.v.) or to themselves.
The bacterial response to chemotherapeutic drugs and their role as screening agents in quantitative studies of bacterial mutation and recombination is well known. In blue-green algae, the use of antibiotics to screen resistant strains has recently started (Kumar, 1964;Singh et al., 1965), and little is known about the characteristics of resistant strains. We report the isolation and properties of streptomycin and penicillin resistant strains of Phorraidium mucicola.
๐ SIMILAR VOLUMES