A conscious dog model for assessing the
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Shui-Mei Khoo; Glenn A. Edwards; Christopher J.H. Porter; William N. Charman
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Article
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2001
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John Wiley and Sons
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English
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๐ 1 views
Postprandial administration of halofantrine (Hf), an important antimalarial, leads to 3-and 12-fold increases in oral bioavailability in humans and beagles, respectively, and corresponding 2.4-fold and 6.8-fold decreases in metabolic conversion to desbutylhalofantrine (Hfm). Factors contributing to