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Sensitivity analysis and robust experimental design of a signal transduction pathway system

✍ Scribed by Hong Yue; Martin Brown; Fei He; Jianfang Jia; Douglas B. Kell

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
468 KB
Volume
40
Category
Article
ISSN
0538-8066

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✦ Synopsis

Abstract

Experimental design for cellular networks based on sensitivity analysis is studied in this work. Both optimal and robust experimental design strategies are developed for the IκB‐NF‐κB signal transduction model. Based on local sensitivity analysis, the initial IKK intensity is calculated using an optimal experimental design process, and several scalarization measures of the Fisher information matrix are compared. Global sensitivity analysis and robust experimental design techniques are then developed to consider parametric uncertainties in the model. The modified Morris method is employed in global sensitivity analysis, and a semidefinite programming method is exploited to implement the robust experimental design for the problem of measurement set selection. The parametric impacts on the oscillatory behavior of NF‐κB in the nucleus are also discussed. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 40: 730–741, 2008

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