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Sensitive high-performance liquid chromatographic method for the determination of labetalol diastereoisomers in plasma samples without derivatization

✍ Scribed by J. Grellet; P. Michel-Gueroult; D. Ducint; M.C. Saux

Publisher
Elsevier Science
Year
1994
Weight
428 KB
Volume
652
Category
Article
ISSN
0378-4347

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## Abstract In this study, we investigated a simple, sensitive and reliable liquid chromatography‐fluorescence detection method for the determination of memantine hydrochloride in rat plasma which was based on derivatization with 9‐fluorenylmethyl chloroformate (FMOC‐Cl). For the first time, FMOC‐C