Sensitive biological tests for medical grade plastics I. Toxicity of organo-tin stabilizers
✍ Scribed by Marcel Nimni
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 359 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Tissue implantation and the measurement of inflammation by the dye emravasation technique are sensitive and rapid methods for screening plastics for toxicity. The subcutaneous and the intramuscular implantation of polyvinyl chloride plastics contaming organo-tin stabilizers produces severe local tissue reaction. T h e degree of extravasation of trypan blue at the site of the injection of a suitable plastic extract is also an indication of compatibility with animal tissues. Mineral oil was found to be a suitable, nonirritating agent for extracting the plastic. The same techniques are suitable for screening raw materials before incorporation into the plastic formulation. Tin stabilizers, such as dibutyltin dilaurate, caused irritation i n dilutions as great as 1 :10,000.
LASTIC MATERIALS, because of their versatility P and low cost, find increasing usage in the pharmaceutical and medical fields (1). To keep pace with varying needs in diversified applications, the plastic industry has developed many different formulations (2, 3). It has been of primary importance to investigate carefully among other properties, the biological inertness of the plastics which contact drugs or tissues. Sensitive bioassay procedures are used to detect any toxic effects of the plastic resins themselves, as well as of the ingredients which may be added to the basic polymers for purposes of stability, flexibility, or coloring. The effectiveness of the subcutaneous or intramuscular implantation in animals, as a means of detecting acute and chronic toxicity of plastics, has been re-