✦ LIBER ✦

Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells

✍ Scribed by Lei Li; Lee Zou

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 145 KB
Volume: 94
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.20355

No coin nor oath required. For personal study only.

✦ Synopsis

The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. Unlike typical signal transduction mechanisms that respond to one or a few stimuli, checkpoints can be activated by a broad spectrum of extrinsically or intrinsically derived DNA damage or replication interference. Recent investigations have shed light on how the damage and replication checkpoints are able to respond to such diverse stimuli. The activation of checkpoints not only attenuates cell cycle progression but also facilitates DNA repair and recovery of faltered replication forks, thereby preventing DNA lesions from being converted to inheritable mutations. Recently, more checkpoint targets from the cell cycle and DNA replication apparatus have been identified, revealing the increasing complexity of the checkpoint control of the cell cycle. In this article, we discuss current models of the DNA damage and replication checkpoints and highlight recent advances in the field.

📜 SIMILAR VOLUMES

Nicotine affects the signaling of the de

Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents

✍ Naoyoshi Onoda; Alisar Nehmi; David Weiner; Sunita Mujumdar; Randolph Christen; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB 👁 1 views

## Abstract ## Background Growing evidence suggests that tobacco can affect the responsiveness of cancer cells to treatment, particularly those of head and neck cancer. This article describes the effects of nicotine on the signaling of the death pathway, resulting in a decreased cytotoxicity of va

Indole-3-carbinol activates the ATM sign

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

✍ Christine T. Brew; Ida Aronchik; Jocelyn C. Hsu; Joon-Ho Sheen; Robert B. Dickso 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 968 KB

## Abstract The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti‐proliferative response in human breast cancer cell lines. Treatment of the immortalized human mammary epithelial cell line MCF10A with I3C induced a G1 cell cy

Multiple mechanisms of action of ZR2002

Multiple mechanisms of action of ZR2002 in human breast cancer cells: A novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA

✍ Fouad Brahimi; Zakaria Rachid; Qiyu Qiu; James P. McNamee; Yu-Jiang Li; Ana M. T 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 276 KB 👁 2 views

## Abstract The mechanism of action of ZR2002, a chimeric amino quinazoline designed to possess mixed EGFR tyrosine kinase (TK) inhibitory and DNA targeting properties, was compared to those of ZR01, a reversible inhibitor of the same class and PD168393, a known irreversible inhibitor of EGFR. ZR20