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Sensing and signaling during infection in Drosophila

✍ Scribed by Julien Royet; Jean-Marc Reichhart; Jules A Hoffmann

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
174 KB
Volume
17
Category
Article
ISSN
0952-7915

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✦ Synopsis

Most of the progress in dissecting the Drosophila antimicrobial response over the past decade has centered around intracellular signaling pathways in immune response tissues and expression of genes encoding antimicrobial peptide genes. The past few years, however, have witnessed significant advances in our understanding of the recognition of microbial invaders and subsequent activation of signaling cascades. In particular, the roles of peptidoglycan recognition proteins, which have known homologues in mammals, have been recognized and examined at the structural and functional levels.

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