Sensing A Paradigm Shift in the Field of Molecular Recognition: From Selective to Differential Receptors

ChemInform Abstract: Sensing a Paradigm

ChemInform Abstract: Sensing a Paradigm Shift in the Field of Molecular Recognition: From Selective to Differential Receptors

✍ John J. Lavigne; Eric V. Anslyn 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB

NON-AQUEOUS TITRATIONS AS A TOOL IN THE

NON-AQUEOUS TITRATIONS AS A TOOL IN THE STUDY OF MOLECULAR RECOGNITION PHENOMENA. USES IN DISTINGUISHING HYDROGEN BONDING FROM PROTON TRANSFER, THE MEASUREMENT OF COMPLEX INDUCED pKa SHIFTS, AND THE ABILITY TO DISTINGUISH THE CATALYTIC ROLES OF GENERAL ACIDS AND BASES

✍ Christine L. Hannon; Dwayne A. Bell; Anne M. Kelly-Rowley; Larry A. Cabell; Eric 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 2 views

Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the pK a of the donor is far enough above the pK a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. Ho