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Senescence of cultured human fibroblasts: Mitotic versus metabolic time

โœ Scribed by S. Goldstein; D.P. Singal

Book ID
118876427
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
433 KB
Volume
88
Category
Article
ISSN
0014-4827

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๐Ÿ“œ SIMILAR VOLUMES

Senescence of cultured human diploid fib
Senescence of cultured human diploid fibroblasts. Are mutations responsible?
โœ Radhey S. Gupta ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 691 KB

## Abstract Two predictions of the error/mutation hypothesis of cellular sensecence (Orgel, '73) namely, (a) exponential accumulation of somatic mutations during the replicative lifespan and (b) shortening of culture lifespan upon treatment with mutagens have been examined experimentally in a strai