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Senescence of Activated Stellate Cells Limits Liver Fibrosis

✍ Scribed by Valery Krizhanovsky; Monica Yon; Ross A. Dickins; Stephen Hearn; Janelle Simon; Cornelius Miething; Herman Yee; Lars Zender; Scott W. Lowe

Book ID
116353883
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
162 KB
Volume
135
Category
Article
ISSN
0092-8674

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Senescence of activated stellate cells:
Senescence of activated stellate cells: Not just early retirement
✍ JΓΆrg Schrader; Jonathan Fallowfield; John P. Iredale πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 153 KB

Cellular senescence acts as a potent mechanism of tumor suppression; however, its functional contribution to noncancer pathologies has not been examined. Here we show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis. The senescent cells