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Semiconductor radioisotope detector for capillary electrophoresis

✍ Scribed by Stephen L. Pentoney Jr.; Richard N. Zare; Jeff F. Quint

Book ID
104145673
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
880 KB
Volume
480
Category
Article
ISSN
1873-3778

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✦ Synopsis

A simple, semiconductor radioactivity detector for capillary electrophoresis is described. The capillary electrophoresis-radioisotope detector system utilizes a commercially available semiconductor device which is positioned external to the separation channel and which responds directly to impinging y or high-energy /3 radiation.

The system performance is evaluated using synthetic mixtures of 32P-labeled sample molecules and the efficiency of the semiconductor detector (planar geometry) is determined to be approximately 26%. The detection limit is determined to be in the low nanocurie range for separations performed under standard conditions (an injected sample quantity of 1 nCi corresponds to 110 . lo-" moles of 32P). The lower limit of detection is extended to the sub-nanocurie level by use of flow (voltage) programming to increase the residence time of labeled sample components in the detection volume.

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Copper wire amperometric detector for ca
Copper wire amperometric detector for capillary electrophoresis
✍ Charlotte E. Engstrom-Silverman; Andrew G. Ewing πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 393 KB

## Abstract The use of a copper wire amperometric detector for capillary electrophoresis is reported. Detection is accomplished by use of a porous glass joint, which allows amperometric detection at a copper wire electrode inserted in the end of the capillary. An anodic current is produced by a cha