Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 – Cellulose Sulfate
✍ Scribed by Martin Gericke; Aleš Doliška; Jan Stana; Tim Liebert; Thomas Heinze; Karin Stana-Kleinschek
- Book ID
- 102934876
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 632 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
In the present study, blood‐compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM‐D. It was demonstrated that pre‐coating with different amino‐group‐containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer‐by‐layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material.
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