Semi-synthetic penicillins and cephalosporins incorporating a hydroxyamino group

✍ Scribed by Peter H. Bentley; Gerald Brooks

• Book ID: 104225733
• Publisher: Elsevier Science
• Year: 1976
• Tongue: French
• Weight: 222 KB
• Volume: 17
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)93096-x

✦ Synopsis

A previous note' describes the synthesis of semi-synthetic penicillins and oephalosporins incorporating a hydxasino grouping in the side-chain. This paper describes experiments designed to provide the analogous compounds. e.g. l&, containing the a-hydmxyemino grouping. We also offer 6ome observations on the synthesis of severel a-hydroxyemino phenylacetic acid derivatives, which might be applicable elsewhere, in particular to the synthesis of N-hydroxypeptides. 2 PhCHCO-X h &%X=&or&; R, RI = H, alkyl or acyl d 2 X = ACA -; R=R'=H R' 2 X = ACA -; R=COPh,R' =H 2 X=APA -; R=R'=H 2 X=ACA -; B