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Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography–tandem mass spectrometry

✍ Scribed by Gangfeng Wang; Yunsheng Hsieh; YauYi Lau; K.-C Cheng; Kwokei Ng; Walter A Korfmacher; Ronald E White


Book ID
108497343
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
395 KB
Volume
780
Category
Article
ISSN
1873-376X

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A method is described for the evaluation of drug concentrations in plasma and brain from treated rats. The analyte is recovered from plasma or brain homogenate by liquid-liquid extraction and subsequently analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). A simple experimental pr