Semaphorins: Receptor and Intracellular Signaling Mechanisms

✍ Scribed by Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J. Pasterkamp (eds.)

Publisher: Springer-Verlag New York
Year: 2007
Tongue: English
Leaves: 162
Series: Advances in Experimental Medicine and Biology 600
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by a family of proteins called the semaphorins. Originally these protein were identified as "axon guidance cues" important for the formation of nerve tracts but now it is realized that semaphorins subserve several distinct functions in a multitude of organ systems.

This book summarizes our knowledge and makes it available as a useful and comprehensive tool for the scientific community. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems. The book will be of interest to people working in the field as well as those who work in other fields of science and would like to learn more about semaphorins and associated signaling mechanisms.

✦ Table of Contents

Front Matter....Pages i-xiv
The CRMP Family of Proteins and Their Role in Sema3A Signaling....Pages 1-11
GTPases in Semaphorin Signaling....Pages 12-23
Intracellular Kinases in Semaphorin Signaling....Pages 24-37
MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling....Pages 38-51
Signaling of Secreted Semaphorins in Growth Cone Steering....Pages 52-60
Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules....Pages 61-72
Proteoglycans as Modulators of Axon Guidance Cue Function....Pages 73-89
Semaphorin Signals in Cell Adhesion and Cell Migration: Functional Role and Molecular Mechanisms....Pages 90-108
Semaphorin Signaling During Cardiac Development....Pages 109-117
Semaphorin Signaling in Vascular and Tumor Biology....Pages 118-131
Semaphorin Signaling in the Immune System....Pages 132-144
Back Matter....Pages 145-147

✦ Subjects

Neurosciences; Cancer Research; Immunology

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