Self-tolerance: context dependent tuning of T cell antigen recognition
โ Scribed by Zvi Grossman; William E Paul
- Book ID
- 115648023
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 183 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1044-5323
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๐ SIMILAR VOLUMES
Antigen recognition by T cells is a key event in the adaptive immune response. T cells scan the surface of antigen-presenting cells (APCs) or target cells for specific peptides bound to MHC molecules. In the physiological setting, a typical APC presents tens of thousands of diverse endogenous self-d
In this study we investigated the basis for immunity or tolerance to a mouse serum protein, the fifth component of complement (C5). In CS-deficient mice this protein is absent from serum and therefore they are not tolerized. Immunization of CS-deficient mice with C5-sufficient serum generates CD4' T