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Self-Terminating, Oxidative Radical Cyclizations: A Novel Reaction of Acyloxyl Radicals

✍ Scribed by Wille, Uta


Book ID
111858635
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
39 KB
Volume
124
Category
Article
ISSN
0002-7863

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Lithium malonate enolates 4 or 13 are oxidized to the corresponding radicals by ferrocenium hexafluorophosphate (1) or CuCl 2 (2). Trapping by TEMPO (5) to produce 6, dimerization to 7, or radical 5-exo cyclizations are possible subsequent reaction steps following radical generation. The structure o